ALCOHOL DEPENDENT PATIENTS

P- Alcohol dependent person treated with I-NaltrexoneC-AcamprosateO-Are abstinence rate significantly different at 6 months

P- Alcohol dependent person treated with I-NaltrexoneC-AcamprosateO-Are abstinence rate significantly different at 6 months

Introduction

The study at hand aims upon comparing the effectiveness of NaltrexoneC and AcamprosateO for the treatment of alcohol dependence. The alcohol dependence is one of the common and prevailing disorders featured most of the times by deterioration and chronic relapses in the context of numerous efforts at treatment (Boening, Lesch, Spanagel, Wolffgramm, Sinclair, et al., 2001). Numerous meta-analyses and systematic reviews indicate the fact that some of the pharmacological agents can be significantly effective for the purpose of psychosocial treatment of alcohol dependence. Two pharmacotherapy, NaltrexoneC and AcamprosateO, have been known as the promising source in treating the alcohol dependent patients.

The study at hand is concerned with the major problem/opportunity of direct comparison of the efficacy of NaltrexoneC and AcamprosateO in a placebo-controlled double-blind, randomized study. Adding to this, a secondary analysis is performed to assess the association between the depression on the treatment effectiveness and the baseline stages of dependence severity. The possible significance of these investigations was recommended by (i) considerable levels of the range of dependence severity and the baseline emotional distress in the sample, (ii) higher depression rates in the target population, and (iii) rising substantiation suggesting the specify of response to the alcohol pharmacotherapy.

Such a trend of consuming alcohol which may be a cause of creating health problems in the human body is known as the harmful drinking. The topic is of much significance to study due to the fact that too much alcohol dependence may become the reason of physical illness that may include severe pancreatitis, psychological problems like depression, or numerous accidents due to the consumption of alcohol. The harmful drinkers may create in them further problems such as cirrhosis, high blood pressure, heart disease and some other types of severe diseases such as liver, mouth, and breast or bowel cancer. The topic becomes of more importance when the harmful consequences of the alcohol dependence, which goes on to include tolerance, craving, continued drinking, and an obsession with alcohol is observed. The alcohol dependence is also connected with an increase in the domestic violence and criminal activity, along with an enhanced rate of vital physical and mental disorders. There are approximately one third of people living in the United States who consume a big quantity of alcohol which can be acknowledged as alcohol dependence, and alcohol dependence and abuse are linked to over 100,000 deaths which are likely to occur from the alcohol-related injuries and diseases every year (Harwood, 2001).

The pharmacological choices have the current availability of AcamprosateO and NaltrexoneC in the forefront. The pure opioid antagonist is NaltrexoneC, which has been showing positive effects since the time period of early1990s. Though, the action mechanism of this drug is not properly known or studied, yet NaltrexoneC i thought to apply a competitive antagonism in terms of the opioid ...