Drosophila model of Parkinson's disease



Drosophila model of Parkinson`s Disease

General Information of Parkinson's disease

It is a well known fact that Parkinson's disease is the second most widespread disorder and is also the frequent movement disorder. The major function of this disease is that a person diagnosed with this disease loses his muscle control that leads towards the trembling of limbs and head. This happens when the muscles are at rest, they become stiff, slow and loses the balance at a rapid rate. When the symptoms get worse, it becomes quite difficult for the person to walk, interact and complete their simple tasks. The progress of the disease and the extent of the impairment vary to a very large extent from person to person. There are many people who suffer from Parkinson's disease but they tend to live productive life while others become disable very quickly. The most common aspect of the Parkinson disease is the premature death which occurs due to the complications experienced because of the falling related injuries or pneumonia (Emre, Aarsland & Brown, 2007, 1707).

In the United States alone, there are about 1 million people suffering from the Parkinson's disease and the overall ration in worldwide is around 5 million people. This is a very high ratio because the statistics reflects this fact. There are most of the individuals who are diagnosed with this disease after 60 years of age. The approximate ratio of the people who are 60 years old and suffering from this disease is 1%. The approximate ratio of the people who are 80 years old and suffering from this disease is 4%. The overall life expectancy is even increasing at a rapid rate and there is a likelihood that the number of individuals suffering from this Parkinson's disease is at high rate. There is a high need to address the issues associated with the disease. Therefore, all the issues related to the study will be discussed in detail (Janvin, Larsen, Aarsland & Hugdahl, 2006, 1349).

Features and Effects of alpha-synuclein in Parkinson disease

In the rare cases of Parkinson's disease, the alpha-synuclein gene is produced in a very large quantity or in a much abnormal form which causes toxicity in the brain cells. This particular factor leads to the neurological disorder for some patients that become a major problem. In addition, alpha-synuclein is the most important element of the Lewy bodies, which clearly suggests that protein aggregation might have a vital role in the Parkinson disease. There are most of the findings which supports the literature related to the development of the Parkinson's disease therapies that can certainly decrease the effect of alpha-synuclein gene expression or block its aggressive content. These therapies have the highest ability to mainly prevent or cause a delay in the onset of Parkinson's disease. The function of therapies also assists in slowing the progression of the disease (Karlsen, Larsen, Tandberg & Maeland, 1998, 450).

One of the most important facts is that the content of alpha-synuclein pathology exists in ...