MAST CELL AND WOUND HEALING IN DIABETES

Mast Cell and Wound Healing In Diabetes

Mast Cell and Wound Healing In Diabetes

Summary

The mast cell is a type of white blood cell that normally found in the connective tissue, bone marrow, lymph nodes and spleen tissue (spleen). The mastoblastes are young mast cells.

The connective tissue acts as a liaison between the organic parts. There is also a prop (skeleton, support) between different tissues and organs. (Marrero, 2007) It is constituted by connective tissue cells, the connective fibers and elastic fibers.

Mast cells appear to play other functions as well. As they gather around the wound, they also play an important role in wound healing. For example, a typical hair itching about the cause of healing may be tried before that secretes histamine from mast cells. Researchers also think that mast cells have a role in the growth of blood vessels. No mast cell or may be a few were found with one, which indicates that, we may not be able to survive with very few mast cells.

Introduction

Mast cell is present mainly in the granular tissue, which is characterized by the presence in its cytoplasm containing numerous granules of chemical mediators such as serotonin, histamine, tryptase and heparin. When in contact with an allergen and present it to the surface IgE specific one, it degranulation and release of these mediators very quickly, through a mechanism of exocytosis. It starts and immediate allergic reactions, sometimes severe as anaphylactic shock which causes hypotension. (Eyre, 2004)The same activation induces a more delayed (several hours) the synthesis of many cytokines (like TNF-alpha) and chemokines (like interleukin-8)

Mast cells are cells that synthesize and store histamines and found in most body tissues, particularly just below the epithelial surfaces, serous cavities and around blood vessels. In an allergic response, an allergen stimulates the release of antibodies which bind to the surface of mast cells.

A mast cell is a connective tissue cell that contains granules rich in histamine and heparin. Mast cells play an important role in protecting the body and are involved in wound healing and defense against pathogens, but are known more for his role in allergies and anaphylaxis. In this case, by releasing histamine and other metabolism-regulating substances, it happens that when a large amount of antigen to mast cells surrounding these, as a defense, suddenly released all its contents known endocrinal the anaphylactic shock. Mast cells also contain serotonin (Stadelmann, 1998)

Mast cells and mast cells originate in stem cells from bone marrow, acting in mediating inflammatory processes. Have a core of average size in the middle, with chromatin. Optical microscopy can only be distinguished in the cytoplasm granules of large membrane-bound and visible with the PAS technique. These granules are the property of being metachromatic, i.e. have the ability to change the color of the dye with which they are dyed. An example of this can be observed using hematoxylin, blue, with which we can see that the granules stain red / pink. The same happens with dyes such as methylene ...