MICROBIOLOGY

Microbiology

Microbiology

For this paper I have selected “Microbe -induced T cell apoptosis: subversion of the host defense system?” by Michael C. Jendro , Lars Köhler, Jens G. Kuipers and Henning Zeidler.2002.

Introduction

The cells of multicellular organisms are equipped with a self-destruct program called apoptosis, in order to ensure the homeostasis of the organism. Reduced lymphocyte compartment after recovery from infection is under control of the mechanism. However, lymphocyte apoptosis may be Achilles tendon available for microbes to undermine the immune system. Evidence that the cumulation of germs to use this mechanism to kill microbes specific T cells. We present an overview microbe-induced T-cell apoptosis discuss implications for the pathogenesis of microbial infections. Usual role of lymphocytes during infection is to impose a threat of apoptotic infected cells, the subject of this review shows the opposite, lymphocytes as targets for a microbe-induced death. Hypothesis

The hypothesis of this article: microbes have the potential to use physiological cell suicide program is implemented in T-cells for their own purposes. They are able to induce apoptosis of T cells and thereby increase their chances of survival in an unfriendly environment. We present first the different pathways leading to T-cell apoptosis, the details of various strategies for using microbes for induction, and finally discuss the implications for microbial survival. Significant results & Its Future research

In contrast to viral diseases where the induction of apoptosis of T is estimated as an integral part of the pathogenesis of this potentially important mechanism of disease is recognized for microbial infection. Role models of HIV infection, where the induction of apoptosis of CD4 + T-cells the virus is a characteristic and prognostic most important feature of this infection. Apoptosis is a highly regulated process of programmed cell death, which is required for development and homeostasis of multicellular organisms. General advantage ...