Quantitative Analysis of Ventricular Repolarisation in Patients with Genetically Determined Arrhythmogenic Syndromes Using High-Resolution Continuous 12-Lead Ambulatory Holter Recordings

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Acknowledgement

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Abstract

The short QT syndrome has been lately recognised as a genetic ion conduit dysfunction. This new clinical entity is affiliated with an incidence of sudden cardiac death, syncope, and atrial fibrillation in else healthy one-by-ones. The distinctive ECG pattern consists of an abnormally short QT interval, a short or even absent ST segment and narrow T waves.Long QT intervals in the ECG have been associated with sudden cardiac death. Little is renowned about the clinical significance of a short QT interval. Tremendous paces have been made in latest years in the diagnosis and remedy of rapid cardiac death in individuals with an evidently normal heart. Algra et al. first suggested that patients with a short QT gap had an increased risk of rapid death by investigating Holter recordings retrospectively in 1993. It was not until 2000 that Gussak et al. proposed a short QT syndrome as a new inherited clinical syndrome. In 2003, the definitive familial link between short QT syndrome and rapid death was illustrated by Gaita et al. By analysis of reference standards gap Schwartz and Wolff were to propose the first partnership between the gap of LQTS and sudden death in patients with Genetically Determined Arrhythmogenic Syndromes . Chevalier et al later reported that the gradient of the LQTS / BS sample vulnerability described with sudden death in patients after Genetically Determined Arrhythmogenic Syndromes and colleagues Atig that variability LQTS gap grew rapidly recognize cardiac death in patients after myocardial damage. Us before you judge with a method to assess the ability of the strain of LQTS and BS degrees develop over the last gaps in patients with LQTS syndrome currently assesses the patient's susceptibility to symptoms. This group evaluated the dynamics of LQTS mix clear sudden changes autonomously mediated changes of the intervals that have the return of property and the dependence of the velocity, the distance of LQTS.

Quantitative Analysis of Ventricular Repolarisation in Patients with Genetically Determined Arrhythmogenic Syndromes Using High-Resolution Continuous 12-Lead Ambulatory Holter Recordings

CHAPTER 1: INTRODUCTION

Introduction

The definition of the congenital Long QT Syndrome (LQTS) is based on QT duration, but thorough QT- and T-wave evaluation has not been performed to date. To evaluate the influence of QT rate-correction formulas in LQTS diagnosis, 12- lead Lead Ambulatory Holter Recordings (LAHRs) were recorded in 27 subjects from a single family with LQTS. Based on QT duration corrected by Bazett formula (QTc), 4 men were considered to have ...