Review of 3 Original Research Articles on Diabetes

Review of 3 Original Research Articles on Diabetes

Introduction

The development of a reliable and accessible to centers based care, to diagnose the syndrome of insulin resistance (SRI) is one of the priority problems of endocrinology. In the past 10 years, the basic and clinical research has shown that impaired insulin sensitivity in peripheral tissues is a key pathogenic component, a risk factor, or at least a metabolic marker of entities as important and as wide distribution such as diabetes mellitus and obesity, hypertension and ischemic heart disease, hypertriglyceridemia and hyperuricemia. The importance and high prevalence of this syndrome is necessary that we have analytically simple and valid methods for diagnosis that can be used in large populations of susceptible individuals (Gustavsson, Lao, et al, 2008).

It now has high reliability methods for detecting disorders of insulin sensitivity in humans, as the glucose clamp, developed by Andrew and another the proof of intravenous glucose tolerance with multiple extractions mathematical modeling and calculation of insulin sensitivity, developed by Bergman (Iezzi, Kouri, et al, 2004). The performance of both tests is complex, laborious and expensive.

This paper proposes a series of provisional indicators of hyperinsulinemia and insulin resistance, for use in our environment, as a first approximation to the solution to this problem, until it is counted with national or international standards that unifies this approach, as occurs with the diagnosis of disorders of glucose tolerance and diabetes mellitus (Gao, Reavey-Cantwell, et al, 2000). These criteria will be used, as an initial validation to study the frequency of insulin resistance and hyperinsulinism in a similar group of individuals who are overweight or obese.

Hypothesis

H1: Synaptotagmin (Syt) is involved in Ca2+ regulated secretion and has been suggested to serve as a general Ca2+ sensor on the membrane of secretory vesicles in neuronal cells.

H0: Synaptotagmin (Syt) is not involved in Ca2+ regulated secretion and does not serve as a general Ca2+ sensor on the membrane of secretory vesicles in neuronal cells.

Methods

We calculate the indicators from the results of the insulin values ??during the test of oral glucose tolerance in the group of 60 people under study with normal glucose tolerance, recruited from the staff of both sexes who came to Consultation of the National Institute of Reproduction Endocrinology. On performing the clinical examination showed no acute or chronic metabolic disorders, had normal weight and denied personal or family history of diabetes mellitus. Additionally, we conducted the same study in a group of similar origin, in which the body mass index was above 27. We test oral glucose tolerance after 16 h of fasting. Were administered a dose of 75 g of glucose in a volume of 100 mL of water orally. We obtained blood samples for laboratory tests before administration of the stimulus and at 30, 60, 120 and 180 min thereafter (Gustavsson, Lao, et al, 2008).

Given that the values ??of the determinations of insulin, both fasting and during stimulation tests, show great dispersion and asymmetric distribution in the different studied populations, we ...