TABLET PRODUCTION USING WET GRANULATION

Tablet Production Using Wet Granulation



Abstract

Tablet Granulation building is described as a two-step process. The first step includes a mixture of wet granulation of dust and particles compressed into tablets in the second step. For wet granulation, tablet pharmaceutical process modeling, the construction and comparison of two forms. The first form involves trampling power (CS), the disintegration time (DT) and eJection force (EF) and in terms of wet granulation and tableting steps and the composition of the dust mixture of the tablets of the process variable. These forecasts in the supplementary variables, the second model also uses the personal property of intermediate particles in order to advance the prediction performance of the first model. Model 1, the method must be found at the beginning of the method used to set the variable composition of the tablet and mix with the exact nature of proposed particle. Mode 2 is used in daily production, each new batch of granulation. Particle characteristics may not agree with the batch, as such as air humidity, temperature or other unidentified sources of the function uninhibited. With 2 main forms of these differences into account, and CS and DT is expected to be better than Model1. The second form included in the assessment of the particle properties has the advantage of not only the predictive capabilities, but the second model provides the additional possibility of using the second step of the process control design. The design of this command to adjust the variable step tablet, so tablets, to better meet regulatory requirements. The particle characteristics are highly collinear, and then on the first step, the smallest rectangular part of the regression method has been used in the method of modeling the variable may be.

Tablet production by wet granulation

Introduction

In this paper, the physical properties of particles and the composition of powder mixture variables and process variables are granulation, tabletting of steps to improve tablet properties of modeling. Therefore, the tablet production process is described as a two-step process. In the first step is to wet granular powder mixture to improve the performance of the mixture of the tablet. Several process variables can be adjusted to change, such as time and granulation granulation granulation liquid physical properties. Described in the granulation particle size distribution, mobility parameters and quantity down and explore. In the second step particles compressed into tablets. Here, such as compression strength and Water particles other process variables can be set to produce the characteristics of tablets. Tablet features include the Chief Secretary, DT, and the Exchange Fund. Fig. 1 shows the tablet manufacturing with wet granulation step, two step process. The powder mixture is described in three stages, as a mixture of phosphor powder, granules, and finally as a flat-panel T G process variables PV1 and PV2 describe the transition from one stage to another.

Particle characteristics are highly collinear. In addition, the physical characteristics of particles affected by the mixture and the first step, the granulation process ...