FERTILIZATION FAILURE

Fertilization Failure



Fertilization Failure

Introduction

There were a total of 7628 IVF cases within the 5 years and a half interval, between 02nd January 2007 and 20th June 2012, and data from all the patients were examined retrospectively. No patients' identification was used in my analysis from the total number of cycles, there were 3000 cycles with cIVF (among which the incidence of FF was 37.44%), 4248 cycles with ICSI (the incidence of FF was 22.6%), 70 cycles with ½ cIVF/ ½ ICSI (0% FF) and 303 cycles with other type of procedure (0% FF; e.g. egg freezing, egg donor). I restricted my investigation to the first attempt to avoid statistical problems with autocorrelation.

ICSI is the method of choice to support infertility. Its indications cover the severe impairment of mobility, the use of epididymal and testicular spermatozoa and the repeated failure of IVF. Whatever the age and type of sperm, the fertilization rate in ICSI extends from 70 to 80%. It is estimated that the total failure of fertilization in IVF is 5 to 10% against only 1-3% of ICSI; this failure seems to be mostly the result of a low number of mature oocytes or a failure of oocyte activation. Failed fertilization was defined as the absence of two pronuclei in the embryo on the next day after the oocyte exposure to sperm. Total failed fertilization was defined as the failure of all the available oocytes to fertilize and low fertilization was defined as the fertilization of a small number of oocytes from all oocytes available for insemination/injection. Normal fertilization is characterised by the presence of bipronucleate embryos on the day following exposure to the sperm.

Data Analysis

For the purpose of this study the researcher has used descriptive statistics that can measure the outcome of frequency of complete FF with respect to female age, origin and quality of cumulus oocyte masses COCs available for insemination, date of oocyte retrieval, centre of oocyte retrieval, number of cycle that patients have had to our centre.

Descriptive statistics can summarize the primary results obtained by observation or experiment. All calculations of descriptive statistics can be reduced to the grouping of data on their values, building a distribution of frequencies, identifying the central tendencies of the distribution and, finally, to estimate the scatter of the data relative to the central tendency was found.

Descriptive Statistics

N

Minimum

Maximum

Mean

Std. Deviation

Maternal Age

1230

22

47

36.70

4.201

Valid N (listwise)

1230

The table above shows the descriptive statistics for the maternal age, it can be seen that on average the maternal age of women are around 37 years. The minimum maternal age that has been recorded is 22, while the maximum is 47 years. In the past an older mother often meant a woman who already had a large family and was their fifth, sixth or even seventh child. The number of births in these women often led to complications. Nowadays, it is generally referred to a woman than elderly mother when they decided to found a family later. It is then generally fit and well ...