MAU

Relationship between Ferritin Level And Time Needed For Next Venesection In Haemochromatosis Patient In Last 4 Years In Mau

Relationship between Ferritin Level & Time Needed For Next Venesection In Haemochromatosis Patient In Last 4 Years In Mau

Background of the study

Hemochromatosis is a condition that causes excess absorption of iron from the digestive tract. Over time, the excess iron accumulates in tissues throughout the body, leading to iron overload. (Suzuki, 2008: p. 30-5) Early identification and treatment of hemochromatosis can prevent complications. General health is improved after several weeks of vene-sections, transaminases return to normal, and hyperpigmentation lessens. In the setting of stage 4 complications, some manifestations of disease may be irreversible. Although regression of cirrhosis is sometimes observed following venesection therapy, whether this decreases the risk for the development of hepatocellular carcinoma requires further study.

Problem Statement

Treatment typically involves regular phlebotomy (removal of blood) since blood cells contain an abundance of iron. Hemochromatosis is caused by the excessive absorption of iron. The exact process is still being studied. As a general rule, a number of chemical events take place that regulate how much iron is absorbed. Central to this process is a gene called HFE. (Suzuki, 2008: p. 30-5) Ferritin is a protein that reflects the body's stores of iron. Therefore, the results of this test may be normal early in the course of hemochromatosis. Ferritin levels greater than 300 ng/mL in men and 200 ng/mL in women support a diagnosis of hemochromatosis. However, ferritin levels can also be increased by many common disorders other than hemochromatosis.

Purpose of the study

The purpose of the study will be to examine the relationship between Ferritin Level & Time Needed For Next Venesection In Haemochromatosis Patient In Last 4 Years In Mau.

Rationale of the study

The term hemochromatosis encompasses at least four types of genetic iron overload conditions, most of them recently distinguished from one another as a result of the identification of a series of genes related to iron metabolism. At least three of these entities (HFE hemochromatosis, juvenile hemochromatosis and transferrin receptor 2 hemochromatosis) involve systemic hepcidin deficiency as a key pathogenetic factor.

Significance fo the study

Venesection (phlebotomy) constitutes the primary modality for reducing iron overload. Although patients should be advised to avoid ingesting large quantities of vitamin C-containing food (since ascorbic acid can both increase iron intestinal absorption and facilitate the release of iron from the storage sites, which has been responsible for rare instances of lethal cardiac failure), nutritional advice otherwise has little place. Chelation therapy using long-term subcutaneous infusions of desferrioxamine (Desferal®) is indicated only in the very rare setting of significant contraindications to venesection (technical impossibility of blood withdrawal due to the venous status, coexisting anemia).

Research Questions

RQ1: Explain the relationship among ferritin level and time needed for next venesection in haemochromatosis patient

RQ2: Examine the different treatments for Haemochromatosis patient in MAU?

RQ3: Exaplain in detail the ferritin level and venesection in haemochromatosis patient?

Literature review

Previous research depicts that treatment of haemochromatosis is done by a simple procedure called a phlebotomy (removal of ...