Non-Coding RNAs In DNA Damage And Repair

Non-Coding RNAs In DNA Damage And Repair

Introduction

Scientific critique of a research article is based upon the knowledge and complete understanding of the reader related to the topic. Critical analysis of research article requires a focused discussion of each part of the selected research paper. The critical analysis comprises of information from introduction, discussion, methodology, results and conclusion. The research article for which the critique analysis is established is by Vivek Sharma & Tom Misteli (2013) on “Non-coding RNAs in DNA Damage and Repair”. The research article is about non-coding RNAs and their increased utility as playing a central part in diverse biological processes. The article also highlight the issue how DNA damage due to DNA damage response (DDR) inputs a complex signaling cascade of reactions which involves induction of multiple ncRNA species. The research literature of the issue is indicative that DNA damage is responsible to induce ncRNA and is contributory in the regulation of cell cycle, apoptosis and DNA repair. All this together plays an important role in maintaining the genome stability which has been verified in the results of the research (Sharma & Misteli, 2013).

Discussion

In this review we will be able to understand how effectively the role of ncRNAs in emergent in DNA damage and repair. Therefore the article proves the efficiency of scientific research and approach. The advancement in the field of genetics is also towards and inclining trend and it has become possible to manage the DNA repair and damage. DNA harm leads to the particular induction connected with a number of ncRNA variety. The author have also discussed about many researches on ncRNAs from the DNA harm answer have got so far devoted to the particular role connected with miRNAs. It can be obvious in which miRNA induction ...