Osteoporosis and the Pathological Process

Osteoporosis and the Pathological Process

Osteoporosis

Osteoporosis is a multifactorial disease characterized by a decrease in mass and impaired bone structure, which maintains normal ratio of mineralized and non-mineralized matrix. Osteoporosis is the result of an imbalance in the functional activity of osteoblasts and osteoclasts, which results in an excess of bone resorption over bone formation. Osteoporosis occurs in many diseases characterized by generalized loss of bone substance; with all divisions of the skeleton characterized by increased fragility and susceptibility to fracture. Osteoporosis is characterized by localized involvement in the pathological process, in the restricted areas of the skeleton; ...