PHARMACOKINETICS

Pharmacokinetics



Pharmacokinetics

Scenario 1

Amoxicillin/clavulanate is a widely prescribed combination of beta-lactam antibiotic and beta-lactamase inhibitor available in different conventional dosage forms for peroral delivery and is considered as a broad-spectrum antibiotic for the treatment of a wide range of bacterial infections, including upper and lower respiratory tract infections and infections of the skin and soft-tissue structures. The clavulanate component inhibits beta-lactamase-mediated inactivation, thereby maintaining amoxicillin's bactericidal activity (Athamna, 2004, pp.247-251).

Amoxicillin has an oral bioavailability of around 90%. Following an oral dose of amoxicillin maximal plasma concentrations occur at approximately 2 hours. The pharmacokinetics of amoxicillin is not affected by food, and ...