POLIOMYELITIS

Economic Analysis And Valuation Of Mass Vaccination Against Poliomyelitis To Young Children In 1000 Villages Of Country X

Economic Analysis And Valuation Of Mass Vaccination Against Poliomyelitis

Vaccination In Young Children In 1000 Village Of Poland

The history of poliomyelitis in Young Children In 1000 Village of Poland is shown in Table 1.8 Approximately 3,000 cases of polio occurred in 1951, giving an incidence of 12.7 per 100,000 population. From 1952 through 1957 the annual total of cases of poliomyelitis varied from approximately 1,000 to 2,500. In 1958, a major epidemic produced over 6,000 cases of polio, or an incidence of 21.0 per 100,000 population. In the postepidemic year of 1959, the incidence dipped to 3.9 per 100,000, influenced in part perhaps by the killedvirus vaccination of most Polish children between the ages of six months and six years during the spring of 1959. Two inoculations of a killed-virus vaccine were administered. In the spring of 1960, an additional one million children in the 7- to 11-year-old group were also given killed-virus vaccine. With regard to the age distribution of poliomyelitis in Young Children In 1000 Village of Poland, the majority of cases occurred in children younger than five years. In distinction to certain tropical countries, however, the incidence of poliomyelitis in children above five years of age was far from negligible, accounting for approximately 30 per cent of the total. About 5 per cent to 10 per cent of cases each year occurred in adults (i.e., those 18 or older) . The population chosen for vaccination was the age group of six months through 14 years, which consisted of 8,949,900 children. Vaccination with one strain in a single province was completed in one to two weeks. Two provinces were vaccinated with the Type 1 strain in June, 1959. Beginning in October, 1959, these vaccinations were extended to other provinces, gradually embracing the territory of the whole country. Vaccinations with Type 1 were completed in February, 1960. After a lapse of at least four weeks after the administration of Type 1, oral vaccinations with Type 3 (W-Fox) strain were begun in the individual provinces and were completed between November, 1959, and May, 1960. Of the age group chosen for vaccination, 7,239,000, or 80.9 per cent, were fed the CHAT Type 1 virus, and 6,818,500, or 76.2 per cent, were fed the W-Fox Type 3 virus. About 420,000 had received Type 1 only and an undetermined smaller number of children underwent vaccination with Type 3 only. The numbers vaccinated in each province, as well as the month in which vaccination was performed, are given in Table 2. The dosage administered was 200,- 000, 50 per cent tissue culture infective doses for Type 1, and 100,000 TCID5o for Type 3.

Serologic Response

The serological status of the Polish population as determined by a prevaccination serologic survey is analyzed in Table 3. The survey, comprising over 2,300 specimens, was performed in early 1959, before the extensive use of killedor live-virus ...