Immunity To Infection With Listeria Monocytogenes

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Immunity To Infection With Listeria Monocytogenes

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Innate And Adaptive Immunity To Infection With Listeria Monocytogenes

Listeria monocytogenes, an opportunistic pathogen foodborne persistent, one of the leading causes of death that causes food-borne infection. The newly identified complete genome sequence of the strain of L. egde monocytogenes and pathogenic species closely related to the understanding of Listeria innocua strain CLIP11262 best of the bases of the genetic code of the virulence of L. monocytogenes and expand our understanding of the evolution of these Listeria species. Both genomes of teaching a large number of surface transport proteins and narrow. (Gupta, 1997)

Comparison of the genome reveals a perfect system of two Listeria genomes. Strongly opposed to other bacteria also showed a high conservation of genome organization of the species Listeria monocytogenes, Staphylococcus aureus and Bacillus bacteria group of low G + C. Different G + C, a series of strain-specific genes suggests intensive cross transport gene. The identification of protein coding 55 kb are more than homology with proteins of Salmonella enterica serovar Typhimurium synthesis of vitamin B12, as well as those needed for the dissipation of ethanolamine and propanediol further indicates the completion of a horizontal transfer gene and a complete way possible role of this locus in anaerobic growth in the host. (Kuo, 1993)

A significant part of our understanding of the functions of the immune system has learned from examining the innate and adaptive immune response to experimental infection with Listeria monocytogenes in mice. murine listeriosis include the complex interaction between host and pathogen, and has an attractive model for some important reasons infections served. The infection is highly reproducible, and the bacterial load in the guest lists with ease. sublethal doses of L. monocytogenes induces a strong immune response, bacterial clearance results. (Kuo, 1993) A molecular level, L. monocytogenes is genetically tractable allows the elimination of individual virulence factors or the insertion of genes, different antigens. was used in this article provides an update on recent developments in the area of infection and immunity of L. monocytogenes as a model pathogen. (Kuo, 1993)

Based on research, both in culture and living tissue, it is clear that L. monocytogenes has the ability to enter nonphagocytic cells. A designated day, two surface proteins involved in implementing exactly L. monocytogenes in cultured cells have been distinuished molecular level. These two proteins are INLA (internalin) and InlB. invasion genes were known to the defense of a Tn1545 mutant library of L. monocytogenes for the reduction of invasiveness in intestinal epithelial cell line Caco-2. Three non-invasive mutants in which the transposon was obtained is injected into a region upstream of two open reading frames, INLA and InlB. (Gupta, 1997)

Complementation of the mutant restored invasion noninvasive INLA Caco-2 cells. Also, when issued INLA L. innocua was said in that other invasive non-invasive, the non-pathogenic Listeria species, suggesting that INLA may be suitable for entry. The second gene function identified by the rack-mount terminations of each of these two genes and ...
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