Molecular goals of best-selling drugs

Molecular targets of best-selling drugs

Molecular targets of best-selling drugs

Avonex

Avonex is a medication constructed by a biotechnological method from one of the naturally-occurring interferons (a type of protein). It is made up of precisely the identical amino acids (major constituents of proteins) as the interferon beta discovered in the human body. CHEMICAL NAME INTERFERON BETA

In a controlled clinical trials in relapsing MS, those taking the medication had a reduced risk of disability progression, experienced fewer exacerbations, and showed a reduction in number and size of active lesions in the brain (as shown on MRI) when compared with the group taking a placebo. In a subsequent study of patients who had skilled a lone demyelinating event in the optic cheek, spinal cord, or mindstem, and had lesions usual of MS on mind MRI, Avonex significantly delayed the time to a second exacerbation, and therefore to a clinically definite diagnosis of MS. (Wills 2008)

Approval by the U.S. Food and pharmaceutical management (FDA) AVONEX (Interferon beta-1a) is a 166 amino acid glycoprotein with a predicted molecular weight of approximately 22500 daltons.

Avonex is accepted by the U.S. Food and pharmaceutical Administration (FDA) for the remedy of patients with relapsing forms of MS to slow the accumulation of physical disability and decrease the frequency of clinical exacerbations. Patients with MS in whom efficacy has been illustrated include those who have experienced a first clinical episode and have MRI features reliable with MS. (Janeele 2008)

Zyloric

Zyloric, Zyloprim is used in the remedy of many symptoms of gout, encompassing acute attacks, tophi (collection of uric acid crystals in the tissues, especially round junctions), junction decimation, and uric unpleasant stones. Chemical name Allopurinol is used for the treatment of Gout which is a form of arthritis characterized by increased blood levels of uric acid. Zyloprim works by decreasing uric unpleasant output in the body, therefore stopping crystals from forming. Zyloric, Zyloprim is furthermore used to organise the bigger uric unpleasant grades in the blood of persons with certain cancers, such as leukemia. It is also prescribed to organise some kinds of kidney pebbles. Zyloric. Brand Mixtures, Target 1 Number of Residues, 1355. Target 1 Molecular Weight, 146426 (Wills 2008)



Adalimumab

Chemical name Humira Adalimumab is a synthetic (man-made) antibody that works in a similar way to the natural antibodies produced by our immune system. Our natural antibodies recognise harmful substances and bind to them, ...