TYPE 2 DIABETES AND COGNITIVE DECLINE

Prospective Study Of Type 2 Diabetes and Cognitive Decline In Women Aged 70-80 Years

Introduction

The emerging picture of type 2 diabetes genetics engages differently assembled gene variants, each humbly increasing risk with ecological exposure. However, the relevance of these genes for infection proposition has not been extensively tested. Type 2 diabetes is the most widespread pattern of diabetes, accounting for 90-95% of cases. In type 2 diabetes, the body does not respond properly to insulin, a condition known as insulin resistanc high blood pressure during pregnance. Insulin is a hormone made by the pancreas that regulates how the body converts sugar (glucose) into energy.(Zimmet P, 2001, 144)

20 million people in the U.S. have diabetes, but many cases can be prevented.

Discussion and Analysis

Type 2 diabetes is a complex trait where common genetic variants having unassuming modest individual effects together and interproceed with ecological components to modulate the risk of the disease. Initial efforts to recognize type 2 diabetes susceptibility genes favored the genome-wide linkage approach and nominee gene association studies. A few common polymorphisms have been widely replicated in populations of different ethnic descents, including: the E23K single nucleotide polymorphism (SNP) in KCNJ11 coding for Kir6.2, two intronic polymorphisms in the protease calpain-10 and more recently TCF7L2 variants, which have the most important risk effect (9,10). An association of the G-30A polymorphism in the ß-cell-specific promoter of glucokinase (GCK) was reported with elevated fasting glycemia and birth weight, gestational diabetes, impaired glucose regulation and a higher prevalence of type 2 diabetes in patients with coronary artery disease(Zimmet P, 2001, 144).

Findings after the study

This can inflict excessive fetal weight benefit, which can inflict delivery complications as well as increased risk of breathing complications and upper future risk for the child towards grow obesity and model two diabetes. In supplement to threatening the fetus, gestational diabetes can also start dangerous medicinal dangers for the mother, such as preeclampsia, a condition that involves high blood pressure during pregnancy.

There are important steps we can take to reduce the risk. It is an interactive tool to assess the risk of diabetes and provides personalized tips for prevention. Anyone can use it, but it is most accurate for people who have never any type of blood sugar problems. If you have had problems with blood sugar levels in the past, be sure to talk to your doctor about your risk of developing diabetes.

Causes

Type 2 diabetes is initiated by insulin opposition, in which the body does not properly use insulin. Generally, diabetes type 2 is thought to issue from a combination of genetic factors along with lifestyle factors such as obesity, high alcohol intake, and being sedentary. Genetic mutations expected sway parts of the insulin gene and diverse other physiologic components engaged in the regulation of blood sugar. Some uncommon types of diabetes are exactly connected to genes. Diabetes Secondary to Other Conditions. Conditions that damage or destroy the pancreas, such as pancreatitis (inflammation), pancreatic surgery, or certain industrial chemicals can cause ...