JOURNAL ARTICLE CRITIQUE

Journal Article Critique: Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

Journal Article Critique: Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

During severe sepsis, activation of the inflammatory cascade leads to cell damage and organ failure. In recent years, the importance of the cross-talk between coagulation and inflammation in severe sepsis has been well defined. This has led to the hypothesis that inhibitors of coagulation might have a dual effect, that is, interruption of the cascades of both coagulation and inflammation. Recombinant human activated protein C (rhAPC, drotrecogin alfa (activated), Xigris®) is ...