Testosterone Replacement Therapy

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Testosterone Replacement Therapy

Testosterone Replacement Therapy


Testosterone is a hormone produced by the male sex glands, which is responsible for the normal development of male sexual characteristics. Testosterone (TT) is also important for building muscle, producing normal levels of red blood cells, bone growth, well being and the realization of sexual function. Lack of testosterone is not a common cause of impotence. However, in cases where the impotence is due to a decrease in testosterone production in the body, may address this problem testosterone replacement therapy.

Hypogonadism is a complex clinical syndrome that is confirmed by the biochemical diagnosis of testosterone deficiency. Therefore, the TT replacement therapy (TRT) is used to treat this condition, in the case of testicular origin in hypothalamic or pituitary failure. Hypogonadism is associated with other comorbidities such as heart disease, diabetes and infection by human immunodeficiency virus (HIV). Also, osteoporosis can be a consequence of deficient TT.

Too little testosterone is not good for the male body and weakens the muscle, sexual desire, potency, enhance memory and thinking skills. Also promotes testosterone deficiency apparently different diseases such as Parkinson's, Alzheimer's and osteoporosis. The normal testosterone level is between 20 and 60 nmol per liter of blood. Decreases the testosterone level below should be trying to increase testosterone levels again.


Recent advances in new formulations of the TRT enable a more convenient administration, which allows achieving levels similar to the physiological hormone. The TT has circadian variations in men, with a morning peak plasma concentrations (6 to 8 hours) and a valley between 18 and 20. It also describes a circannual rhythm, with highest levels in late summer and early fall and lower concentrations in late winter and early spring period. Production of the TT in the hypothalamus is regulated by the pulsatile secretion of gonadotropin-releasing hormone (GnRH), which stimulates ...
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